Article
Genetic correlates of early accelerated infant growth associated with juvenile-onset type 1 diabetes.
Pediatric diabetes - 1 May 2012
Kharagjitsingh Av, de Ridder Maj, Alizadeh Bz, Veeze Hj, Bruining Gj, Roep Bo, Koeleman Bobby Pc
Abstract excerpt
OBJECTIVE: We previously showed that accelerated growth predisposing to development of childhood-onset type 1 diabetes (T1D) is restricted to the first year after birth. We assessed whether this phenomenon of increased early growth is associated with variants of two genes, insulin-like growth factor-1 (IGF1) and insulin variable number of tandem repeats (INS-VNTR), whose products are components of the growth...
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