Article
Balancing selection and the evolution of functional polymorphism in Old World monkey TRIM5alpha.
Proceedings of the National Academy of Sciences of the United States of America - 12 Dec 2006
Newman Ruchi M, Hall Laura, Connole Michelle, Chen Guo-Lin, Sato Shuji, Yuste Eloisa, Diehl William, Hunter Eric, Kaur Amitinder, Miller Gregory M, Johnson Welkin E
Abstract excerpt
Retroviral restriction factor TRIM5alpha exhibits a high degree of sequence variation among primate species. It has been proposed that this diversity is the cumulative result of ancient, lineage-specific episodes of positive selection. Here, we describe the contribution of within-species variation to the evolution of TRIM5alpha. Sampling within two geographically distinct Old World monkey species revealed...
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