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Article

Identification of a Genomic Reservoir for New TRIM Genes in Primate Genomes

1 Dec 2011

Abstract excerpt

Tripartite Motif (TRIM) ubiquitin ligases act in the innate immune response against viruses. One of the best characterized members of this family, TRIM5α, serves as a potent retroviral restriction factor with activity against HIV. Here, we characterize what are likely to be the youngest TRIM genes in the human genome. For instance, we have identified 11 TRIM genes that are specific to humans and African apes...

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PMID: 22144910
DOI: 10.1371/journal.pgen.1002388

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Identification of a Genomic Reservoir for New TRIM Genes in Primate GenomesPMID 22144910Read ↗

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