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Article

Loss of SFRP1 promotes ductal branching in the murine mammary gland.

BMC developmental biology - 28 Aug 2012

Gauger Kelly J, Shimono Akihiko, Crisi Giovanna M, Schneider Sallie Smith

Abstract excerpt

BACKGROUND: Secreted frizzled-related proteins (SFRPs) are a family of proteins that block the Wnt signaling pathway and loss of SFRP1 expression is found in breast cancer along with a multitude of other human cancers. Activated Wnt signaling leads to inappropriate mammary gland development and mammary tumorigenesis in mice. When SFRP1 is knocked down in immortalized non-malignant mammary epithelial cells, the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22928951
DOI: 10.1186/1471-213X-12-25
PMCID: PMC3482146

Genes

SFRP1

Provenance

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Related research

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Loss of SFRP1 promotes ductal branching in the murine mammary gland.PMID 22928951Read ↗

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