Article
Genome dynamics and transcriptional deregulation in aging.
Neuroscience - 14 Apr 2007
Busuttil R, Bahar R, Vijg J
Abstract excerpt
Genome instability has been implicated as a major cause of both cancer and aging. Using a lacZ-plasmid transgenic mouse model we have shown that mutations accumulate with age in a tissue-specific manner. Genome rearrangements, including translocations and large deletions, are a major component of the mutation spectrum in some tissues at old age such as heart. Such large mutations were also induced by hydrogen...
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