Transgenic mouse models for studying mutations in vivo: applications in aging research.

doi:10.1016/s0047-6374(97)00107-3

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Article

Transgenic mouse models for studying mutations in vivo: applications in aging research.

Mechanisms of ageing and development - 1 Dec 1997

Vijg J, Dollé M E, Martus H J, Boerrigter M E

Abstract excerpt

To study mutation accumulation in the DNA of somatic cells and tissues during aging in vivo, a transgenic mouse model has been constructed. The model harbors plasmid vectors, containing the lacZ reporter gene, integrated head to tail at various chromosomal locations. Procedures have been worked o...

Topics

Aging
Animals
Artifacts
Mice
Mice, Transgenic
Models, Genetic
Mutation
Plasmids
Reproducibility of Results

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