Article
Transgenic mouse models for studying mutations in vivo: applications in aging research.
Mechanisms of ageing and development - 1 Dec 1997
Vijg J, Dollé M E, Martus H J, Boerrigter M E
Abstract excerpt
To study mutation accumulation in the DNA of somatic cells and tissues during aging in vivo, a transgenic mouse model has been constructed. The model harbors plasmid vectors, containing the lacZ reporter gene, integrated head to tail at various chromosomal locations. Procedures have been worked out to efficiently recover the plasmids into E. coli host cells. A positive selection system, permitting only E. coli...
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