Article
Large genome rearrangements as a primary cause of aging.
Mechanisms of ageing and development - 30 Apr 2002
Vijg Jan, Dollé Martijn E T
Abstract excerpt
In his introductory chapter of the Mutation Research special issue on 'Genetic Instability and Aging', the late Bernard Strehler provided some historical perspectives on the long-standing hypothesis that aging is primarily caused by changes in the genome of somatic cells (Strehler, 1995, Mutat. Res. 338 (1995) 3). Based on his own findings of a loss of ribosomal RNA gene copies in postmitotic tissues of dogs as...
Topics
- Aging
- Animals
- DNA Repair
- Gene Rearrangement
- Humans
- Models, Genetic
- Mutation