Article
A genome-wide association study identifies protein quantitative trait loci (pQTLs).
PLoS genetics - 9 May 2008
Melzer David, Perry John R B, Hernandez Dena, Corsi Anna-Maria, Stevens Kara, Rafferty Ian, Lauretani Fulvio, Murray Anna, Gibbs J Raphael, Paolisso Giuseppe, Rafiq Sajjad, Simon-Sanchez Javier, Lango Hana, Scholz Sonja, Weedon Michael N, Arepalli Sampath, Rice Neil, Washecka Nicole, Hurst Alison, Britton Angela, Henley William, van de Leemput Joyce, Li Rongling, Newman Anne B, Tranah Greg, Harris Tamara, Panicker Vijay, Dayan Colin, Bennett Amanda, McCarthy Mark I, Ruokonen Aimo, Jarvelin Marjo-Riitta, Guralnik Jack, Bandinelli Stefania, Frayling Timothy M, Singleton Andrew, Ferrucci Luigi
Abstract excerpt
There is considerable evidence that human genetic variation influences gene expression. Genome-wide studies have revealed that mRNA levels are associated with genetic variation in or close to the gene coding for those mRNA transcripts - cis effects, and elsewhere in the genome - trans effects. The role of genetic variation in determining protein levels has not been systematically assessed. Using a genome-wide...
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