Article
Mapping common regulatory variants to human haplotypes.
Human molecular genetics - 15 Dec 2005
Pastinen Tomi, Ge Bing, Gurd Scott, Gaudin Tiffany, Dore Carole, Lemire Mathieu, Lepage Pierre, Harmsen Eef, Hudson Thomas J
Abstract excerpt
Inter-individual variation in gene expression has proven to be in part governed by genetic determinants, which may be trans- or cis-acting. The underlying cause of cis-acting regulatory variation has been identified in only a handful of the hundreds of genes shown to display differential allelic expression. In this report, we describe a systematic effort to map common cis-acting variants in 64 genes, using...
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