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Article

Effects of altered FcγR binding on antibody pharmacokinetics in cynomolgus monkeys.

mAbs - 1 Jan 2000

Leabman Maya K, Meng Y Gloria, Kelley Robert F, DeForge Laura E, Cowan Kyra J, Iyer Suhasini

Abstract excerpt

Antibody interactions with Fcγ receptors (FcγRs), like FcγRIIIA, play a critical role in mediating antibody effector functions and thereby contribute significantly to the biologic and therapeutic activity of antibodies. Over the past decade, considerable work has been directed towards production of antibodies with altered binding affinity to FcγRs and evaluation of how the alterations modulate their therapeutic...

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Source

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Identifiers

PMID: 24492343
DOI: 10.4161/mabs.26436
PMCID: PMC3896603

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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