Article
Disease-associated casein kinase I delta mutation may promote adenomatous polyps formation via a Wnt/beta-catenin independent mechanism.
International journal of cancer - 1 Mar 2007
Tsai I-Chun, Woolf Margaret, Neklason Deborah W, Branford William W, Yost H Joseph, Burt Randall W, Virshup David M
Abstract excerpt
The Wnt signaling pathway is critical for embryonic development and is dysregulated in multiple cancers. Two closely related isoforms of casein kinase I (CKIdelta and epsilon) are positive regulators of this pathway. We speculated that mutations in the autoinhibitory domain of CKIdelta/epsilon might upregulate CKIdelta/epsilon activity and hence Wnt signaling and increase the risk of adenomatous polyps and colon...
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