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Casein kinase I epsilon interacts with mitochondrial proteins for the growth and survival of human ovarian cancer cells

18 Jun 2012

Abstract excerpt

Epithelial ovarian cancer is the leading cause of death among gynaecologic cancers in Western countries. Our studies have shown that casein kinase I-epsilon (CKIε), a Wnt pathway protein, is significantly overexpressed in ovarian cancer tissues and is associated with poor survival. Ectopic expression of CKIε in normal human ovarian surface epithelial cells and inhibition of CKIε in ovarian cancer cells and in...

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PMID: 22707389
DOI: 10.1002/emmm.201101094

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