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Article

Modulatory role of DR4- to DQ8-restricted CD4 T-cell responses and type 1 diabetes susceptibility.

Diabetes - 1 Dec 2006

Ge Xinhui, Piganelli Jon D, Tse Hubert M, Bertera Suzanne, Mathews Clayton E, Trucco Massimo, Wen Li, Rudert William A

Abstract excerpt

This study addressed an important biological question, namely how certain HLA molecules modulate the disease risk conferred by other HLA molecules. The HLA molecules under investigation were HLA-DQ8 and -DR4, the two most prevalent HLA class II alleles found in Caucasian type 1 diabetic patients. A panel of human GAD (hGAD65)-specific CD4 T-cell lines and hybridomas was generated to serve as detection reagents...

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Share to Antigen-Presenting Cells
Share to CD4-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 1

Share to Glutamate Decarboxylase

Share to HLA-DQ Antigens

Share to HLA-DR4 Antigen

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Source

Identifiers

PMID: 17130492
DOI: 10.2337/db06-0680

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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