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Article

The peptide-binding motif of HLA-DR8 shares important structural features with other type 1 diabetes-associated alleles.

Genes and immunity - 1 Oct 2011

Muixí L, Gay M, Muñoz-Torres P M, Guitart C, Cedano J, Abian J, Alvarez I, Jaraquemada D

Abstract excerpt

The objective of this study was to characterize the peptide-binding motif of the major histocompatibility complex (MHC) class II HLA-DR8 molecule included in the type 1 diabetes-associated haplotype DRB1(*)0801-DQA1(*)0401/DQB1(*)0402 (DR8-DQ4), and compare it with that of other diabetes-associated MHC class II alleles; DR8-bound peptides were eluted from an HLA-DR homozygous lymphoblastoid cell line. The...

Topics

Alleles
Amino Acid Motifs
Amino Acid Sequence
Cell Line, Transformed
Diabetes Mellitus, Type 1
HLA-DR Serological Subtypes
Humans
Models, Molecular
Molecular Sequence Data
Peptides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Binding

Protein Conformation

Sequence Alignment

Source

Identifiers

PMID: 21654843
DOI: 10.1038/gene.2011.26

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