Article
Molecular mechanisms underlying HLA-DR-associated susceptibility to autoimmunity.
International journal of cardiology - 1 Aug 1996
Matsushita S, Fujisao S, Nishimura Y
Abstract excerpt
We analyzed structural motifs of peptides bound to HLA-DR4 (DRB1*0405 and DRB1*0406) and DR9 (DRB1*0901) and found that: (a) AxxBxC motif where A, B, and C are hydrophobic, hydrophobic, and neutral, respectively, is important for binding to DR4; (b) Gln (Q) or Ser at position C allow high-affinit...
Topics
- Amino Acid Sequence
- Autoantigens
- Autoimmune Diseases
- Cell Line, Transformed
- Disease Susceptibility
- Gene Frequency
- Genetic Predisposition to Disease
- Genetics, Population
- HLA-DR Antigens
- Humans
- Insulin
- Japan
- Molecular Sequence Data
- Peptide Fragments
- Takayasu Arteritis