Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular mechanisms underlying HLA-DR-associated susceptibility to autoimmunity.

International journal of cardiology - 1 Aug 1996

Matsushita S, Fujisao S, Nishimura Y

Abstract excerpt

We analyzed structural motifs of peptides bound to HLA-DR4 (DRB1*0405 and DRB1*0406) and DR9 (DRB1*0901) and found that: (a) AxxBxC motif where A, B, and C are hydrophobic, hydrophobic, and neutral, respectively, is important for binding to DR4; (b) Gln (Q) or Ser at position C allow high-affinity binding specific to DRB1*0406 which is strongly associated with insulin autoimmune syndrome; (c) among human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Disease Susceptibility
Share to Gene Frequency

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genetics, Population

Share to HLA-DR Antigens

Share to Molecular Sequence Data

Source

Identifiers

PMID: 9119530
DOI: 10.1016/s0167-5273(96)88776-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular mechanisms underlying HLA-DR-associated susceptibility to autoimmunity.PMID 9119530Read ↗

Allele specificity of structural requirement for peptides bound to HLA-DRB1*0405 and -DRB1*0406 complexes: implication for the HLA-associated susceptibility to methimazole-induced insulin autoimmune syndrome.Semantic proximity Read ↗

A new model defines the minimal set of polymorphism in HLA-DQ and -DR that determines susceptibility and resistance to autoimmune diabetes.Semantic proximity Read ↗

Molecular basis for HLA-DQ associations with IDDM.Semantic proximity Read ↗

Differences in self-peptide binding between T1D-related susceptible and protective DR4 subtypes.Semantic proximity Read ↗

Molecular mechanisms of HLA association with autoimmune diseases.Semantic proximity Read ↗

Next-Generation HLA Sequence Analysis Uncovers Seven HLA-DQ Amino Acid Residues and Six Motifs Resistant to Childhood Type 1 Diabetes.Semantic proximity Read ↗

Molecular analyses of HLA class II-associated susceptibility to subtypes of autoimmune diseases unique to Asians.Semantic proximity Read ↗

Associations of human leukocyte antigens with autoimmune diseases: challenges in identifying the mechanism.Semantic proximity Read ↗

Immunogenetics of autoimmune diseases in Asian Indians.Semantic proximity Read ↗

Functional consequences of HLA-DQ8 homozygosity versus heterozygosity for islet autoimmunity in type 1 diabetes.Semantic proximity Read ↗

What is the basis for HLA-DQ associations with autoimmune disease?Semantic proximity Read ↗

[Association of HLA molecules with autoimmune diseases].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.