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Article

Abnormal insulin-like growth factor 1 signaling in human osteoarthritic subchondral bone osteoblasts.

Arthritis research & therapy - 1 Jan 2006

Massicotte Frédéric, Aubry Isabelle, Martel-Pelletier Johanne, Pelletier Jean-Pierre, Fernandes Julio, Lajeunesse Daniel

Abstract excerpt

Insulin-like growth factor (IGF)-1 is a key factor in bone homeostasis and could be involved in bone tissue sclerosis as observed in osteoarthritis (OA). Here, we compare the key signaling pathways triggered in response to IGF-1 stimulation between normal and OA osteoblasts (Obs). Primary Obs were prepared from the subchondral bone of tibial plateaus of OA patients undergoing knee replacement or from normal...

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PMID: 17129375
DOI: 10.1186/ar2087
PMCID: PMC1794522

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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