Dibutyryl cyclic adenosine monophosphate differentially regulates cell proliferation in low and high alkaline phosphatase SaOS-2 human osteosarcoma cells: evidence for mediation by the insulin-like growth factor-II system.

Abstract excerpt

In the present study, we have sought to determine whether a given signal transduction pathway can have diverse effects on subpopulations of cells of a lineage depending upon the stage of differentiation. To test this hypothesis, we selected the cyclic adenosine monophosphate (cAMP) signal transduction pathway because of its recognized importance in mediating the actions of many hormones, e.g., parathyroid hormone...

Topics

• Alkaline Phosphatase
• Bucladesine
• Carrier Proteins
• Cell Division
• Culture Media
• Humans
• Insulin-Like Growth Factor Binding Proteins
• Insulin-Like Growth Factor II
• Osteosarcoma
• Phenotype