Article
Local leptin production in osteoarthritis subchondral osteoblasts may be responsible for their abnormal phenotypic expression.
Arthritis research & therapy - 1 Jan 2010
Mutabaruka Marie-Solange, Aoulad Aissa Mohamed, Delalandre Aline, Lavigne Martin, Lajeunesse Daniel
Abstract excerpt
INTRODUCTION: Leptin is a peptide hormone with a role in bone metabolism and rheumatic diseases. The subchondral bone tissue plays a prominent role in the pathophysiology of osteoarthritis (OA), related to abnormal osteoblast (Ob) differentiation. Although leptin promotes the differentiation of Ob under normal conditions, a role for leptin in OA Ob has not been demonstrated. Here we determined if endogenous...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.