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Article

Local leptin production in osteoarthritis subchondral osteoblasts may be responsible for their abnormal phenotypic expression.

Arthritis research & therapy - 1 Jan 2010

Mutabaruka Marie-Solange, Aoulad Aissa Mohamed, Delalandre Aline, Lavigne Martin, Lajeunesse Daniel

Abstract excerpt

INTRODUCTION: Leptin is a peptide hormone with a role in bone metabolism and rheumatic diseases. The subchondral bone tissue plays a prominent role in the pathophysiology of osteoarthritis (OA), related to abnormal osteoblast (Ob) differentiation. Although leptin promotes the differentiation of O...

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Identifiers

PMID: 20141628
DOI: 10.1186/ar2925
PMCID: PMC2875652

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20141628-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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