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Article

Association between a functional single nucleotide polymorphism in the MDM2 gene and sporadic endometrial cancer risk.

Gynecologic oncology - 1 Mar 2007

Walsh Christine S, Miller Carl W, Karlan Beth Y, Koeffler H Phillip

Abstract excerpt

OBJECTIVES: MDM2 is an important negative regulator of the p53 tumor suppressor protein. A naturally occurring T/G single nucleotide polymorphism (SNP) in the MDM2 gene promoter, SNP309, causes an increase in MDM2 protein levels and impairment of p53 tumor suppressor activity. SNP309 occurs at a relatively high frequency in the general population and has been associated with accelerated tumorigenesis in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Neoplasm

Share to Endometrial Neoplasms

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Share to Promoter Regions, Genetic

Share to Proto-Oncogene Proteins c-mdm2

Source

Identifiers

PMID: 17123590
DOI: 10.1016/j.ygyno.2006.10.008

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association between a functional single nucleotide polymorphism in the MDM2 gene and sporadic endometrial cancer risk.PMID 17123590Read ↗

MDM2 SNP309 polymorphism contributes to endometrial cancer susceptibility: evidence from a meta-analysis.Semantic proximity Read ↗

MDM2 SNP309 is associated with endometrial cancer risk.Semantic proximity Read ↗

MDM2 SNP309 is associated with endometrial cancer susceptibility: a meta-analysis.Semantic proximity Read ↗

Association between MDM2 SNP309 polymorphism and endometrial cancer risk in Polish women.Semantic proximity Read ↗

The MDM2 promoter polymorphism SNP309T-->G and the risk of uterine leiomyosarcoma, colorectal cancer, and squamous cell carcinoma of the head and neck.Semantic proximity Read ↗

Common variant on MDM2 contributes to endometrial cancer susceptibility: evidence based on 7 studies.Semantic proximity Read ↗

Relationship Between Murine Double Minute 2 (MDM2) T309G Polymorphism and Endometrial Cancer Risk: A Meta-Analysis.Semantic proximity Read ↗

Impact of MDM2 promoter SNP55 (rs2870820) on risk of endometrial and ovarian cancer.Semantic proximity Read ↗

SNP55, a new functional polymorphism of MDM2-P2 promoter, contributes to allele-specific expression of MDM2 in endometrial cancers.Semantic proximity Read ↗

Association of MDM2 SNP309 and TP53 Arg72Pro polymorphisms with risk of endometrial cancer.Semantic proximity Read ↗

Murine double-minute 2 homolog single nucleotide polymorphism 309 and the risk of gynecologic cancer.Semantic proximity Read ↗

MDM2 promoter polymorphism SNP309 contributes to tumor susceptibility: evidence from 21 case-control studies.Semantic proximity Read ↗

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