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Impact of MDM2 promoter SNP55 (rs2870820) on risk of endometrial and ovarian cancer.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals - 1 Jun 2021

Helwa Reham, Gansmo Liv B, Bjørnslett Merete, Halle Mari Kyllesø, Werner Henrica M J, Romundstad Pål, Hveem Kristian, Vatten Lars, Dørum Anne, Lønning Per E, Knappskog Stian

Abstract excerpt

BACKGROUND: While large GWAS analyses have not found convincing associations between MDM2 promoter SNP55 and gynaecological cancers, SNP55 is in linkage disequilibrium with two other functional SNPs in the same promoter, likely to obscure associations between single SNPs and cancer risk. Here, we assessed the impact of SNP55 on risk of endometrial and ovarian cancer, including sub-analyses stratified for other...

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PMID: 33645339
DOI: 10.1080/1354750X.2021.1891291

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Impact of MDM2 promoter SNP55 (rs2870820) on risk of endometrial and ovarian cancer.PMID 33645339Read ↗

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MDM2 SNP309 is associated with endometrial cancer susceptibility: a meta-analysis.Semantic proximity Read ↗

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