The -2518bp promoter polymorphism at CCL2/MCP1 influences susceptibility to mucosal but not localized cutaneous leishmaniasis in Brazil.

doi:10.1016/j.meegid.2010.04.006

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Article

The -2518bp promoter polymorphism at CCL2/MCP1 influences susceptibility to mucosal but not localized cutaneous leishmaniasis in Brazil.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Jul 2010

Ramasawmy Rajendranath, Menezes Eliane, Magalhães Andrea, Oliveira Joyce, Castellucci Léa, Almeida Roque, Rosa Maria Elisa A, Guimarães Luiz Henrique, Lessa Marcus, Noronha Elza, Wilson Mary E, Jamieson Sarra E, Kalil Jorge, Blackwell Jenefer M, Carvalho Edgar M, de Jesus Amélia Ribeiro

Abstract excerpt

Mucosal leishmaniasis (ML) follows localized cutaneous leishmaniasis (CL) caused by Leishmania braziliensis. Proinflammatory responses mediate CL self-healing but are exaggerated in ML. Proinflammatory monocyte chemoattractant protein 1 (MCP-1; encoded by CCL2) is associated with CL. We explore its role in CL/ML through analysis of the regulatory CCL2 -2518bp promoter polymorphism in CL/ML population samples and...

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Identifiers

PMID: 20430117
DOI: 10.1016/j.meegid.2010.04.006
PMCID: PMC2878927

Genes

CCL2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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