Article
Synergistic and Selective Cancer Cell Killing Mediated by the Oncolytic Adenoviral Mutant AdΔΔ and Dietary Phytochemicals in Prostate Cancer Models.
Human gene therapy - 1 Sept 2012
Adam Virginie, Ekblad Maria, Sweeney Katrina, Müller Heike, Busch Kristina Hammarén, Johnsen Camilla Tørnqvist, Kang Na Ra, Lemoine Nick R, Halldén Gunnel
Abstract excerpt
AdΔΔ is an oncolytic adenoviral mutant that has been engineered to selectively target tumors with deregulated cell cycle and apoptosis pathways. AdΔΔ potentiates apoptotic cell death induced by drugs, including mitoxantrone and docetaxel, which are commonly used to treat prostate cancer. Here, we demonstrate that AdΔΔ can also interact synergistically with dietary phytochemicals known to have anti-cancer...
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