Article
Downmodulation of E1A protein expression as a novel strategy to design cancer-selective adenoviruses.
Neoplasia (New York, N.Y.) - 1 Aug 2005
Jiang Hong, Alemany Ramon, Gomez-Manzano Candelaria, Medrano Diana R, Lemoine Michael G, Olson Melissa V, Alonso Marta M, Lee Ok-Hee, Conrad Charles C, Yung W K Alfred, Fueyo Juan
Abstract excerpt
Oncolytic adenoviruses are being tested as potential therapies for human malignant tumors, including gliomas. Here we report for the first time that a mutation in the E1A gene results in low levels of E1A protein, conditioning the replication of mutant adenoviruses specifically to cancer cells. In this study, we compared the oncolytic potencies of three mutant adenoviruses encompassing deletions within the CR1...
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