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Article

Increased mutations of CD72 transcript in B-lymphocytes from adolescent patients with systemic lupus erythematosus.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology - 1 Dec 2006

Kaneko Utako, Toyabe Shin-ichi, Hara Masanori, Uchiyama Makoto

Abstract excerpt

Recent studies have shown that B cells play a central role in the pathogenesis of systemic lupus erythematosus (SLE). Abnormal expression of molecules engaging in B-cell receptor (BCR) signaling and resultant hyperactivity of B cells has been reported in both mouse models of lupus and patients with SLE. CD72 on B cells is unique in that it regulates BCR signaling both positively and negatively. We analyzed the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17121583
DOI: 10.1111/j.1399-3038.2006.00466.x

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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