Back to search

Article

CD72-semaphorin3A axis; a possible new player in immune regulation

2021-08-25

Abstract excerpt

Semaphorin3A (sema3A) inhibits the activity of B and T cells in autoimmune diseases such as Systemic Lupus Erythematosus (SLE). We have now found that CD72 functions as a novel sema3A binding and signal-transducing receptor. These functions of CD72 are independent of the known sema3A receptor neuropilin-1 (NRP-1). We find that sema3A induces the phosphorylation of CD72 on tyrosine residues and the association of C...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
e89764bb-cbe3-5174-b7e2-665a90141580
DOI
10.1101/2021.08.24.457482
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
CD72-semaphorin3A axis; a possible new player in immune regulationDOI 10.1101/2021.08.24.457482
Semaphorins: Their Dual Role in Regulating Immune-Mediated DiseasesSemantic proximity
Multifaceted Role of Neuropilins in the Immune System: Potential Targets for ImmunotherapySemantic proximity
Expression of S100A8 protein on B cells is associated with disease activity in patients with systemic lupus erythematosusSemantic proximity
The role of immune semaphorins in the pathogenesis of multiple sclerosis: Potential therapeutic targetsSemantic proximity
Semaphorin 4D induces an imbalance of Th17/Treg cells by activating the aryl hydrocarbon receptor in ankylosing spodylitisSemantic proximity
KARAP/DAP12/TYROBP: three names and a multiplicity of biological functionsSemantic proximity
Semaphorin3B promotes an anti-inflammatory and pro-resolving phenotype in macrophages from rheumatoid arthritis patients in a MerTK-dependent manner.Semantic proximity
The role of semaphorins in immune responses and autoimmune rheumatic diseases.Semantic proximity
Semaphorin 3G exacerbates joint inflammation through the accumulation and proliferation of macrophages in the synoviumSemantic proximity
The emerging role of class-3 semaphorins and their neuropilin receptors in oncologySemantic proximity
Human CD72 splicing isoform responsible for resistance to systemic lupus erythematosus regulates serum immunoglobulin level and is localized in endoplasmic reticulum.Semantic proximity
Relationship of S100 Proteins with NeuroinflammationSemantic proximity
Select a neighboring publication to make it the new centre.