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Article

Plasma vitamin values and antiepileptic therapy: case reports of pregnancy outcomes affected by a neural tube defect.

Birth defects research. Part A, Clinical and molecular teratology - 1 Jan 2007

Candito Mirande, Naimi Mourad, Boisson Catherine, Rudigoz Jean-Charles, Gaucherand Pascal, Guéant Jean-Louis, Luton Dominique, Van Obberghen Emmanuel

Abstract excerpt

BACKGROUND: Folic acid supplementation reduces the occurrence of neural tube defects (NTDs); however, it is not clear whether it protects against teratogenic effects of antiepileptic drugs. METHODS: We report the cases of four pregnant women receiving valproic acid therapy, who all had NTD-affected offspring, despite periconceptional 5 mg/day of folic acid supplementation (cases), and investigated homocysteine...

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Identifiers

PMID: 17120234
DOI: 10.1002/bdra.20318

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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