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Article

Influence of the MTHFR genotype on the rate of malformations following exposure to antiepileptic drugs in utero.

European journal of medical genetics - 1 Jan 2000

Kini Usha, Lee Rebecca, Jones Alison, Smith Sarah, Ramsden Simon, Fryer Alan, Clayton-Smith Jill

Abstract excerpt

UNLABELLED: Folate deficiency and the presence of the 677C > T (CT) polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene have been implicated in the causation of malformations in the fetus (particularly cleft lip and palate and neural tube defects). These birth defects are also recognised complications of exposure to antiepileptic drugs (AEDs). In pregnant women with epilepsy, the use of AEDs has...

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Share to Abnormalities, Drug-Induced
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17951123
DOI: 10.1016/j.ejmg.2007.08.002

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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