Antiepileptic drugs, folate one‐carbon metabolism, genetics, and epigenetics: Congenital, developmental, and neuropsychological risks and antiepileptic action

Abstract excerpt

Folate and one-carbon metabolism are fundamental to fetal, embryo, and child development and to brain health at all ages.1, 2 The term folate refers to several naturally occurring reduced folate forms that function as cofactors in the transfer and utilization of one-carbon groups. The folate cycle is a mechanism for the synthesis of methyl groups by the progressive reduction of a carbon unit derived from serine...

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