Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transgenerational adverse effects of valproate? A patient report from 90 affected families

5 Dec 2021

Abstract excerpt

BACKGROUND: Valproate use during pregnancy increases risk in malformations and neurodevelopmental disorders. Data from the experimental setting in mice showed valproate is a direct inhibitor of histone deacetylase, inducing histone hyperacetylation, histone methylation, and DNA demethylation causing congenital malformations with an epigenetic inheritance. We investigated potential transgenerational adverse...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Folate and B Vitamins Research
Share to Pharmacological Effects and Toxicity Studies
Share to Pregnancy and Medication Impact

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34866359
DOI: 10.1002/bdr2.1967

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transgenerational adverse effects of valproate? A patient report from 90 affected familiesPMID 34866359Read ↗

Prenatal exposure to valproate and risk of congenital malformations—Could we have known earlier?—A population‐based cohort studySemantic proximity Read ↗

Valproic acid embryopathy: Report of two siblings with further expansion of the phenotypic abnormalities and a review of the literatureSemantic proximity Read ↗

Epigenetic changes and disturbed neural development in a human embryonic stem cell-based model relating to the fetal valproate syndromeSemantic proximity Read ↗

Transcription Factor Binding and Individual Genetic Risk of Valproate Teratogenicity.Semantic proximity Read ↗

Diagnosis and management of individuals with Fetal Valproate Spectrum Disorder; a consensus statement from the European Reference Network for Congenital Malformations and Intellectual DisabilitySemantic proximity Read ↗

Risk of Adverse Pregnancy Outcomes Associated with Sodium Valproate(VPA): A Disproportionality Analysis Using the FDA Adverse Event Reporting System (FAERS)Semantic proximity Read ↗

<i>In Utero</i>Exposure to Valproic Acid Induces Neocortical Dysgenesis via Dysregulation of Neural Progenitor Cell Proliferation/DifferentiationSemantic proximity Read ↗

A mouse model for valproate teratogenicity: parental effects, homeotic transformations, and altered HOX expressionSemantic proximity Read ↗

In utero Exposure to Valproic Acid throughout Pregnancy Causes Phenotypes of Autism in Offspring Mice.Semantic proximity Read ↗

Antiepileptic medication during pregnancy: does fetal genotype affect outcome?Semantic proximity Read ↗

Transcription factor binding and individual genetic risk for valproate teratogenicitySemantic proximity Read ↗

Epilepsy in Pregnancy—Management Principles and Focus on ValproateSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.