Article
Repeated neural tube defects and valproate monotherapy suggest a pharmacogenetic abnormality.
Epilepsia - 1 Jun 2001
Duncan S, Mercho S, Lopes-Cendes I, Seni M H, Benjamin A, Dubeau F, Andermann F, Andermann E
Abstract excerpt
Valproate (VPA) is an effective, widely used antiepileptic drug. Unfortunately its use in pregnant women is associated with neural tube defects in the offspring. Although the etiology of neural tube defects is multifactorial, there is evidence that underlying genetic susceptibility plays a part. We describe two women taking moderate doses of VPA who repeatedly bore children with neural tube defects, despite...
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