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Article

Lipid defect underlies selective skin barrier impairment of an epidermal-specific deletion of Gata-3

20 Nov 2006

Abstract excerpt

Skin lies at the interface between the complex physiology of the body and the external environment. This essential epidermal barrier, composed of cornified proteins encased in lipids, prevents both water loss and entry of infectious or toxic substances. We uncover that the transcription factor GATA-3 is required to establish the epidermal barrier and survive in the ex utero environment. Analysis of Gata-3 mutant...

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Identifiers

PMID: 17116754
DOI: 10.1083/jcb.200605057

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