Article
Loss of Mpzl3 function causes various skin abnormalities and greatly reduced adipose depots.
The Journal of investigative dermatology - 1 Jul 2014
Leiva Angel G, Chen Anne L, Devarajan Priyadharshini, Chen Zhibin, Damanpour Shadi, Hall Jessica A, Bianco Antonio C, Li Jie, Badiavas Evangelos V, Zaias Julia, Miteva Mariya, Romanelli Paolo, Nouri Keyvan, Cao Wikramanayake Tongyu
Abstract excerpt
The rough coat (rc) spontaneous mutation causes sebaceous gland (SG) hypertrophy, hair loss, and extracutaneous abnormalities including growth retardation. The rc mice have a missense mutation in the predicted Ig protein Myelin Protein Zero-Like 3 (Mpzl3). In this study, we generated Mpzl3 knockout mice to determine its functions in the skin. Homozygous Mpzl3 knockout mice showed unkempt and greasy hair coat and...
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