Article
HDAC3 ensures stepwise epidermal stratification via NCoR/SMRT-reliant mechanisms independent of its histone deacetylase activity.
Genes & development - 1 Jul 2020
Szigety Katherine M, Liu Fang, Yuan Chase Y, Moran Deborah J, Horrell Jeremy, Gochnauer Heather R, Cohen Ronald N, Katz Jonathan P, Kaestner Klaus H, Seykora John T, Tobias John W, Lazar Mitchell A, Xu Mingang, Millar Sarah E
Abstract excerpt
Chromatin modifiers play critical roles in epidermal development, but the functions of histone deacetylases in this context are poorly understood. The class I HDAC, HDAC3, is of particular interest because it plays divergent roles in different tissues by partnering with tissue-specific transcription factors. We found that HDAC3 is expressed broadly in embryonic epidermis and is required for its orderly stepwise...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.