Article
HPV-negative squamous cell carcinoma of the anal canal is unresponsive to standard treatment and frequently carries disruptive mutations in TP53.
British journal of cancer - 14 Apr 2015
Meulendijks D, Tomasoa N B, Dewit L, Smits P H M, Bakker R, van Velthuysen M-L F, Rosenberg E H, Beijnen J H, Schellens J H M, Cats A
Abstract excerpt
BACKGROUND: Human papillomavirus (HPV), p16 expression, and TP53 mutations are known prognostic factors in head and neck squamous cell carcinoma, but their role in squamous cell carcinoma of the anal canal (SCCAC) is less well established. The objective of this study was to determine the prognostic significance of tumour HPV status, p16 and p53 expression, and mutations in TP53 in patients with SCCAC receiving...
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