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Development and Application of a High-Throughput Assay for glmS Riboswitch Activators

1 Apr 2006

Abstract excerpt

Riboswitches are newly-discovered gene control elements that are promising targets for antibacterial drug development. To facilitate the rapid discovery and development of riboswitch-targeted compounds, modern drug discovery techniques such as structure-based design and high-throughput screening will need to be applied. One promising riboswitch drug target is the glmS riboswitch, which upon binding...

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PMID: 17114942
DOI: 10.4161/rna.3.2.3102

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