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Article

Activation of the glmS Ribozyme Confers Bacterial Growth Inhibition.

Chembiochem : a European journal of chemical biology - 2 Mar 2017

Schüller Anna, Matzner Daniel, Lünse Christina E, Wittmann Valentin, Schumacher Catherine, Unsleber Sandra, Brötz-Oesterhelt Heike, Mayer Christoph, Bierbaum Gabriele, Mayer Günter

Abstract excerpt

The ever-growing number of pathogenic bacteria resistant to treatment with antibiotics call for the development of novel compounds with as-yet unexplored modes of action. Here, we demonstrate the in vivo antibacterial activity of carba-α-d-glucosamine (CGlcN). In this mode of action study, we provide evidence that CGlcN-mediated growth inhibition is due to glmS ribozyme activation, and we demonstrate that CGlcN...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28012261
DOI: 10.1002/cbic.201600491

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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