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Article

Endothelial nitric oxide synthase is not necessary for the early phase of ischemic preconditioning in the mouse.

Journal of molecular and cellular cardiology - 1 Mar 2008

Guo Yiru, Li Qianhong, Wu Wen-Jian, Tan Wei, Zhu Xiaoping, Mu Jingyao, Bolli Roberto

Abstract excerpt

It has been proposed that constitutive expression of endothelial NO synthase (eNOS) protects against myocardial ischemia/reperfusion injury in the naive (unstressed) state and that eNOS plays a critical role in the early phase of ischemic preconditioning (PC). We addressed these issues using both a genetic approach (i.e., eNOS null [eNOS(-/-)]) mice and a pharmacologic approach (with the NOS inhibitor...

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Identifiers

PMID: 18291412
DOI: 10.1016/j.yjmcc.2008.01.003
PMCID: PMC3197773

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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