Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function.

Circulation research - 14 Jun 2002

Csiszar Anna, Ungvari Zoltan, Edwards John G, Kaminski Pawel, Wolin Michael S, Koller Akos, Kaley Gabor

Abstract excerpt

We aimed to elucidate the possible role of phenotypic alterations and oxidative stress in age-related endothelial dysfunction of coronary arterioles. Arterioles were isolated from the hearts of young adult (Y, 14 weeks) and aged (A, 80 weeks) male Sprague-Dawley rats. For videomicroscopy, pressure-induced tone of Y and A arterioles and their passive diameter did not differ significantly. In A, arterioles L-NAME...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arterioles
Share to Bridged Bicyclo Compounds, Heterocyclic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydrazines

Share to NADH, NADPH Oxidoreductases

Share to NG-Nitroarginine Methyl Ester

Share to Nitrites

Share to Vasodilation

Share to Xanthine Oxidase

Source

Identifiers

PMID: 12065318
DOI: 10.1161/01.res.0000020401.61826.ea

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function.PMID 12065318Read ↗

Endothelial TERT drives microvascular phenotype associated with coronary artery disease.Semantic proximity Read ↗

Proinflammatory phenotype of coronary arteries promotes endothelial apoptosis in aging.Semantic proximity Read ↗

Reduced microvascular flow-mediated dilation in Syrian hamsters lacking δ-sarcoglycan is caused by increased oxidative stress.Semantic proximity Read ↗

Upregulation of Nox4 by hypertrophic stimuli promotes apoptosis and mitochondrial dysfunction in cardiac myocytes.Semantic proximity Read ↗

Increased superoxide production and altered nitric oxide-mediated relaxation in the aorta of young but not old male relaxin-deficient mice.Semantic proximity Read ↗

Increased endothelium activation and leakage do not promote diastolic dysfunction in mice fed with a high fat diet and treated with L-NAMESemantic proximity Read ↗

Vascular aging in the longest-living rodent, the naked mole rat.Semantic proximity Read ↗

Mitochondrial redox plays a critical role in the paradoxical effects of NAPDH oxidase-derived ROS on coronary endothelium.Semantic proximity Read ↗

Western-type diet induces senescence, modifies vascular function in non-senescence mice and triggers adaptive mechanisms in senescent ones.Semantic proximity Read ↗

Mechanism of the Switch from NO to H <sub>2</sub> O <sub>2</sub> in Endothelium-Dependent Vasodilation in DiabetesSemantic proximity Read ↗

NADPH oxidase-derived reactive oxygen species in the regulation of endothelial phenotype.Semantic proximity Read ↗

Cellular Senescence Mediates Doxorubicin Chemotherapy-Induced Vascular Endothelial Dysfunction: Translational Evidence of Prevention with Senolytic TreatmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.