Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Soluble epoxide hydrolase activation by S-nitrosation contributes to cardiac ischemia-reperfusion injury.

Journal of molecular and cellular cardiology - 1 Sept 2017

Ding Yuzhu, Li Yazi, Zhang Xu, He Jinlong, Lu Dong, Fang Xuan, Wang Yuchen, Wang Jiaxing, Zhang Yuying, Qiao Xinhua, Gan Li-Ming, Chen Chang, Zhu Yi

Abstract excerpt

Cardiac ischemia-reperfusion (I/R) injury always accompanies recanalization treatment for myocardial infarction. Here we found soluble epoxide hydrolase (sEH), which metabolizes cardioprotective epoxyeicosatrienoic acids into less effective diols, was rapidly activated during myocardial reperfusion in both mouse and rat models in expression-independent manner. Similar activation was mimicked by nitric oxide (NO)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epoxide Hydrolases
Share to Hypoxia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myocardial Reperfusion Injury

Share to Nitric Oxide

Share to Nitric Oxide Synthase Type III

Share to Phenylurea Compounds

Share to Piperidines

Share to Solubility

Source

Identifiers

PMID: 28736260
DOI: 10.1016/j.yjmcc.2017.07.006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Soluble epoxide hydrolase activation by S-nitrosation contributes to cardiac ischemia-reperfusion injury.PMID 28736260Read ↗

Inhibition of soluble epoxide hydrolase preserves cardiomyocytes: role of STAT3 signaling.Semantic proximity Read ↗

Ischemia/Reperfusion Injury: Pathophysiology, Current Clinical Management, and Potential Preventive Approaches.Semantic proximity Read ↗

The denitrosylase SCoR2 controls cardioprotective metabolic reprogrammingSemantic proximity Read ↗

Cardioprotective function of inducible nitric oxide synthase and role of nitric oxide in myocardial ischemia and preconditioning: an overview of a decade of research.Semantic proximity Read ↗

Recent Advances in the Role of Hydrogen Sulfide in Ischemia-Reperfusion InjurySemantic proximity Read ↗

Soluble epoxide hydrolase inhibitor, TPPU, attenuates progression of atherosclerotic lesions and vascular smooth muscle cell phenotypic switching.Semantic proximity Read ↗

Formate reduces ischemic injury in the male heart by increasing protein <i>S</i> -nitrosationSemantic proximity Read ↗

Soluble epoxide hydrolase: gene structure, expression and deletion.Semantic proximity Read ↗

S1P lyase: a novel therapeutic target for ischemia-reperfusion injury of the heart.Semantic proximity Read ↗

Soluble epoxide hydrolase is involved in the development of atherosclerosis and arterial neointima formation by regulating smooth muscle cell migration.Semantic proximity Read ↗

Female-favorable attenuation of coronary myogenic constriction via reciprocal activations of epoxyeicosatrienoic acids and nitric oxide.Semantic proximity Read ↗

Allosteric Ensembles Elucidate Mechanisms of Inhibition in Human Soluble Epoxide HydrolaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.