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Targeted Radiosensitization of Cells Expressing Truncated DNA Polymerase β

26 Oct 2010

Abstract excerpt

Ionizing radiation (IR) is an effective anticancer treatment, although failures still occur. To improve radiotherapy, tumor-targeted strategies are needed to increase radiosensitivity of tumor cells, without influencing normal tissue radiosensitivity. Base excision repair (BER) and single-strand break repair (SSBR) contribute to the determination of sensitivity to IR. A crucial protein in BER/SSBR is DNA...

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PMID: 20978197
DOI: 10.1158/0008-5472.can-09-3901

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