Article
Pharmacogenomic genotyping methodologies.
Clinical chemistry and laboratory medicine - 1 Jan 2004
Jannetto Paul J, Laleli-Sahin Elvan, Wong Steven H
Abstract excerpt
"Personalized medicine" based on an individual's genetic makeup is slowly becoming a reality as pharmacogenomics moves from the research setting to the clinical laboratory. Concordance studies between genotype and phenotype have shown that inherited mutations in several key drug-metabolizing enzymes, such as cytochrome P450 ( CYP ) 2D6 , 2C9 , and 2C19 , result in several distinct phenotypes that lead to...
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