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Article

Analysis of Genetic Variation in CYP450 Genes for Clinical Implementation.

PloS one - 1 Jan 2017

Goh Liuh Ling, Lim Chia Wei, Sim Wey Cheng, Toh Li Xian, Leong Khai Pang

Abstract excerpt

BACKGROUND: Genetic determinants of drug response remain stable throughout life and offer great promise to patient-tailored drug therapy. The adoption of pharmacogenetic (PGx) testing in patient care requires accurate, cost effective and rapid genotyping with clear guidance on the use of the results. Hence, we evaluated a 32 SNPs panel for implementing PGx testing in clinical laboratories. METHODS: We designed a...

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PMID: 28046094
DOI: 10.1371/journal.pone.0169233
PMCID: PMC5207784

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VKORC1

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