Article
The ermC leader peptide: amino acid alterations leading to differential efficiency of induction by macrolide-lincosamide-streptogramin B antibiotics.
Journal of bacteriology - 1 Jul 1990
Mayford M, Weisblum B
Abstract excerpt
The inducibility of ermC by erythromycin, megalomicin, and celesticetin was tested with both wild-type ermC and several regulatory mutants altered in the 19-amino-acid-residue leader peptide, MGIFSIFVISTVHYQP NKK. In the model test system that was used, the ErmC methylase was translationally fuse...
Topics
- Amino Acid Sequence
- Anti-Bacterial Agents
- Bacillus subtilis
- Base Sequence
- Chromosome Deletion
- Enzyme Induction
- Kinetics
- Lincosamides
- Macrolides
- Methyltransferases
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Protein Biosynthesis
- Protein Sorting Signals
- Recombinant Fusion Proteins
- Virginiamycin
- beta-Galactosidase