Article
Characterization of HIV-1 integrase N-terminal mutant viruses.
Virology - 30 Mar 2007
Lloyd Aliza G, Ng Yen Shing, Muesing Mark A, Simon Viviana, Mulder Lubbertus C F
Abstract excerpt
During infection, human immunodeficiency virus type 1 integrase engages a number of molecules and mechanisms, both of viral and cellular origin. In one of such instances, integrase is thought to be degraded by the N-end rule proteasome pathway a process that targets the N-terminal residue of its substrates. Here we describe the properties of HIV-1 viruses in which the first amino acid residue of integrase has...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.