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Article

Human immunodeficiency virus type 1 integrase: effect on viral replication of mutations at highly conserved residues

1 Aug 1994

Abstract excerpt

Sequence comparisons of the integrase (IN) proteins from different retroviruses have identified several highly conserved residues. We have introduced mutations at 16 of these sites into the integrase gene of human immunodeficiency virus type 1 and analyzed the phenotypes of the resulting viruses. The viruses were all normal for p24 content and reverse transcriptase activity. In addition, all of the mutants could...

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PMID: 8035478
DOI: 10.1128/jvi.68.8.4768-4775.1994

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