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Article

Natural selection results in conservation of HIV-1 integrase activity despite sequence variability.

AIDS (London, England) - 4 May 2001

Reinke R, Steffen N R, Robinson W E

Abstract excerpt

BACKGROUND: Integration of the HIV genome by integrase is absolutely required for productive infection. OBJECTIVE: To determine the role of natural selection on HIV integrase biology. DESIGN: To study the activities of HIV integrases from a limited panel of North American clinical isolates from HIV-infected patients and to compare these proteins with integrases from two laboratory adapted reference strains...

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Identifiers

PMID: 11399954
DOI: 10.1097/00002030-200105040-00002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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