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Biochemical and virological analysis of the 18-residue C-terminal tail of HIV-1 integrase

19 Oct 2009

Abstract excerpt

BACKGROUND: The 18 residue tail abutting the SH3 fold that comprises the heart of the C-terminal domain is the only part of HIV-1 integrase yet to be visualized by structural biology. To ascertain the role of the tail region in integrase function and HIV-1 replication, a set of deletion mutants that successively lacked three amino acids was constructed and analyzed in a variety of biochemical and virus infection...

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PMID: 19840380
DOI: 10.1186/1742-4690-6-94

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