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Article

Cell-matrix talks: effects on differentiation of hepatocellular carcinoma.

Minerva gastroenterologica e dietologica - 1 Dec 2006

Wu X Z, Chen D

Abstract excerpt

Different event is a process that is dependent on stimulation of extracellular signals, signal transduction and gene express. Malignant transformation of hepatocytes may occur in cirrhosis, which is the result of extracellular matrix (ECM) remodeling. ECM could affect and maintain the differentiated phenotype of hepatocytes by regulating liver transcription factors. Moreover, ECM remodeling is correlated with...

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PMID: 17108870

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