Article
A novel three-dimensional culture system maintaining the physiological extracellular matrix of fibrotic model livers accelerates progression of hepatocellular carcinoma cells.
Scientific reports - 29 Aug 2017
Miyauchi Yuya, Yasuchika Kentaro, Fukumitsu Ken, Ishii Takamichi, Ogiso Satoshi, Minami Takahito, Kojima Hidenobu, Yamaoka Ryoya, Katayama Hokahiro, Kawai Takayuki, Yoshitoshi-Uebayashi Elena Yukie, Kita Sadahiko, Yasuda Katsutaro, Sasaki Naoya, Uemoto Shinji
Abstract excerpt
Liver fibrosis is characterized by the progressive accumulation of extracellular matrix (ECM) and is a strong predictor of hepatocellular carcinoma (HCC) development and progression. However, the effect of ECM in fibrotic livers on HCC cells is poorly understood. The aims of this study were to create a new culture system that retained the natural ECM of fibrotic model livers and to establish whether natural ECM...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.