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Article

Endoplasmic reticulum stress induces a caspase-dependent N-terminal cleavage of RBX1 protein in B cells.

The Journal of biological chemistry - 7 Sept 2012

Shteingart Shimon, Hadar Rivka, Cohen Itamar, Ravid Tommer, Tirosh Boaz

Abstract excerpt

Endoplasmic reticulum (ER) stress develops when the ER is overloaded with too many proteins to fold. This elicits a signaling pathway called the unfolded protein response. The unfolded protein response is physiologically required for the terminal development of B cells into antibody-secreting plasma cells. Ring Box Protein 1 (RBX1) is a 14-kDa protein necessary for ubiquitin ligation activity of the multimeric...

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Source

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Identifiers

PMID: 22822056
DOI: 10.1074/jbc.M111.314583
PMCID: PMC3438954

Genes

RBX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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